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Subscribe to email updates from tutor2u Economics Join s of fellow Economics teachers and students all getting the tutor2u Economics team's latest resources and support delivered fresh in their inbox every morning. You're now subscribed to receive email updates! Print page. Economics Study notes Geoff Riley. More Study notes.
We were the first to uncover that sPLA2-IIa is overexpressed in almost all specimens of human lung cancers examined and is significantly elevated in the blood of lung cancer patients These findings reveal an underlying mechanism of sPLA2-IIa overexpression in lung cancer development and progression. Western blot analysis was performed as previously described Briefly, aliquots of samples with the same amount of protein, determined using the Bradford assay Bio-Rad, Hercules, CA , were mixed with loading buffer final concentrations of The cells were then treated for 24 h.
Each reaction was measured for 10 sec in the Luminometer. ClusPro cluspro.
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Sppider sppider. Such generated models were assessed using structure and sequence-based predictions of protein interaction sites.
This is further supported by Sppider analysis, which predicts additional protein interaction sites within the sPLA2-IIa hairpin. The current study revealed an underlying molecular mechanism of sPLA2-IIa in cancer development and progression. An increasing body of evidence highlights the role of HER3 in lung cancer, which has not been addressed in the targeted therapy.
However, there is no convenient and non-invasive lung cancer biomarker test for determining the optimal targeted therapy and monitoring the therapeutic efficacy. We found that high levels of plasma sPLA2-IIa are significantly associated with advanced stage and decreased overall cancer survival High levels of plasma sPLA2-IIa are significantly associated with advanced stage and decreased overall cancer survival. CA Cancer J Clin. View Article : Google Scholar. Ann Oncol.
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Lung Cancer. J Clin Oncol. J Thorac Oncol. New Engl J Med. Gazdar AF: Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy. Cancer Metastasis Rev. Curr Opin Pharmacol. J Thorac Cardiovasc Surg. Reduced lung-cancer mortality with low-dose computed tomographic screening.
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A critical review of the evidence. Arch Intern Med. Cummings BS: Phospholipase A2 as targets for anti-cancer drugs.